The Mocking Bird

Picture of mockingbirdhttps://scholarsjunction.msstate.edu/cht-sheet-music/11513/thumbnail.jp

Old Black Joe : Foster\u27s Original Theme with Variations

https://digitalcommons.library.umaine.edu/mmb-ps/2661/thumbnail.jp

Dixie\u27s Land

https://digitalcommons.library.umaine.edu/mmb-ps/1123/thumbnail.jp

A Romance of Athlone : Medley Waltz

https://digitalcommons.library.umaine.edu/mmb-ps/2308/thumbnail.jp

American Patrol

https://digitalcommons.library.umaine.edu/mmb-ps/1766/thumbnail.jp

Dress Parade March and Two - Step

https://digitalcommons.library.umaine.edu/mmb-ps/2614/thumbnail.jp

SysML based Design for Variability enabling the Reusability of Legacy Systems towards the support of Diverse Standard Compliant Implementations or Standard Updates: The Case of IEEE-802.15.6 Standard for e-Health Applications

The aim of this paper is to provide a consistent development path enabling the re-usability of in house legacy systems or architectures towards their re-design, in order to ensure compliance with evolving standards, by using the new features of SysML for modelling variants. Modern standards evolve quickly, include advanced functionalities and operations and support diverse implementations. System industries need to cope with such standards changes by modifying their current technologies. This paper shows how a novel engineering process (SysML modelling) could be employed to define consistently the specification and the migration procedure of legacy systems to their variants. Within this work SysML characteristics such as package and block diagrams, are employed, with an emphasis on variability modelling, as a basis for standard compliant architecture implementation, thus providing design flexibility and reusability at several abstraction levels. As an illustration of our proposed method we present models of two variant Physical Layer structures for IEEE-802.15.6 Standard for e-Health Applications. The advanced SysML features are used to target the re-usability of a legacy Narrow-Band (NB) physical layer subsystem for the Wireless Body Area Network standard and to implement the alternative Ultra-Wide Band (UWB). Therefore, we contend that such methods bring potential benefits to those needing to ensure compliance when producing product variants

Responsibility and Human Enhancement

The debate on human enhancement (HE), i.e. intentional effort to improve individuals\u2019 performance with the help of technical or biomedical interventions, has mainly centered on contrasting characterizations about either its moral legitimacy or technical plausibility, reaching an impasse. Looking for a way out of this stalemate, this collection of articles does not formulate prior standards to assess the desirability or legitimacy of enhancement, but explores some possible features for its responsible governance. Based on these assessments, the articles suggest possible approaches to systems design, regulation, and public engagement which can create conditions that allow for the the assumption and assignment of responsibility for HE and its ethical and social implications

Data incongruence and the problem of avian louse phylogeny

Recent studies based on different types of data (i.e. morphological and molecular) have supported conflicting phylogenies for the genera of avian feather lice (Ischnocera: Phthiraptera). We analyse new and published data from morphology and from mitochondrial (12S rRNA and COI) and nuclear (EF1-) genes to explore the sources of this incongruence and explain these conflicts. Character convergence, multiple substitutions at high divergences, and ancient radiation over a short period of time have contributed to the problem of resolving louse phylogeny with the data currently available. We show that apparent incongruence between the molecular datasets is largely attributable to rate variation and nonstationarity of base composition. In contrast, highly significant character incongruence leads to topological incongruence between the molecular and morphological data. We consider ways in which biases in the sequence data could be misleading, using several maximum likelihood models and LogDet corrections. The hierarchical structure of the data is explored using likelihood mapping and SplitsTree methods. Ultimately, we concede there is strong discordance between the molecular and morphological data and apply the conditional combination approach in this case. We conclude that higher level phylogenetic relationships within avian Ischnocera remain extremely problematic. However, consensus between datasets is beginning to converge on a stable phylogeny for avian lice, at and below the familial rank

Activation of chloride transport in CF airway epithelial cell lines and primary CF nasal epithelial cells by S-nitrosoglutathione

BACKGROUND: It has been suggested that low μM concentrations of S-nitrosoglutathione (GSNO), an endogenous bronchodilator, may promote maturation of the defective cystic fibrosis (CF) transmembrane conductance regulator (CFTR). Because nitric oxide (NO) and GSNO levels appear to be low in the CF airway, there is an interest in the possibility that GSNO replacement could be of therapeutic benefit in CF. METHODS: The effect of GSNO on chloride (Cl(-)) transport was investigated in primary nasal epithelial cells obtained from CF patients homozygous for the delF508 mutation, as well as in two CF cell lines (CFBE and CFSME), using both a fluorescent Cl(- )indicator and X-ray microanalysis. Maturation of delF508 CFTR was determined by immunoblotting. RESULTS: Treatment with 60 μM GSNO for 4 hours increased cAMP-induced chloride efflux in nasal epithelial cells from 18 out of 21 CF patients, but did not significantly affect Cl(- )efflux in cells from healthy controls. This Cl(- )efflux was confirmed by measurements with a fluorescent Cl(- )indicator in the CFBE and CFSME cell lines. The effect of GSNO on Cl(- )efflux in CFBE cells could be inhibited both by a specific thiazolidinone CFTR inhibitor (CFTR(inh)-172) and by 4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonic acid (H(2)DIDS). X-ray microanalysis showed that, following 4 hours incubation with 60 μM GSNO, cAMP agonists caused a decrease in the cellular Cl(- )concentration in CFBE cells, corresponding to Cl(- )efflux. GSNO exposure resulted in an increase in the protein expression and maturation, as shown by immunoblot analysis. GSNO did not increase the cytosolic Ca(2+ )concentration in cultured airway epithelial cells. CONCLUSION: Previous studies have suggested that treatment with GSNO promotes maturation of delF508-CFTR, consistent with our results in this study. Here we show that GSNO increases chloride efflux, both in the two CF cell lines and in primary nasal epithelial cells from delF508-CF patients. This effect is at least in part mediated by CFTR. GSNO may be a candidate for pharmacological treatment of the defective chloride transport in CF epithelial cells